Welcome to our first column post from Dr. Melissa Herbranson at Cromwell Medical Clinic and Wellness.
The purpose of this series is to share current, wellness-oriented knowledge that I actively apply in my practice. My mission is to bring cutting-edge wellness services to our rural community—making science-backed mental and physical health strategies accessible to all.
In this edition, we explore The DOSE Effect by neuroscientist TJ Power, a practical guide to understanding and enhancing your brain’s natural feel-good chemicals: Dopamine, Oxytocin, Serotonin, and Endorphins.
In The DOSE Effect, neuroscientist TJ Power delivers a compelling and accessible guide to mental well-being by decoding the brain’s natural pharmacy: Dopamine, Oxytocin, Serotonin, and Endorphins—collectively known as DOSE. Published in early 2025, this book has quickly gained traction for its blend of scientific insight and practical advice aimed at helping readers optimize their emotional health and daily performance.
Power’s central concept is refreshingly simple: by understanding and intentionally boosting these four neurochemicals, we can dramatically improve our motivation, relationships, mood, and stress levels. Each section of the book is dedicated to one of the DOSE chemicals, offering both the neuroscience behind it and actionable strategies to enhance its presence in our lives. Interestingly, The Harvard Study of Adult Development found that the quality of close relationships is the single most important predictor of along, healthy and happy live life, while loneliness is linked to earlier health declines and shorter lives.
Dopamine, the “motivation molecule,” is linked to goal-setting and reward-driven behavior. In our current culture so many of us are using screen time, sugar, alcohol, or nicotine as our dopamine source. Power suggests effortful activities—like setting small, achievable goals—as natural dopamine boosters. Oxytocin, the “connection chemical,” is explored through the lens of social bonding, with recommendations such as five-second hugs and recurring social rituals to foster trust and intimacy. Serotonin, dubbed the “confidence chemical,” is tied to mood regulation, with Power advocating for nature exposure, gut health, and gratitude journaling. Endorphins, the body’s natural painkillers, are activated through laughter, exercise, and even cold water therapy.
What sets The DOSE Effect apart is its balance of scientific depth and everyday practicality. Power doesn’t just explain the brain’s inner workings—he equips readers with tools to make meaningful changes. His writing is clear, engaging, and peppered with relatable anecdotes and modern references, including nods to post-pandemic life and digital overwhelm.
However, the book isn’t without its critiques. Some seasoned self-help readers may find the strategies familiar, and the lack of in-text scientific citations might leave more research-oriented readers wanting more. Still, the book’s empowering tone and holistic approach make it a standout in the wellness genre.
The DOSE Effect offers a roadmap to a healthier, more intentional life. It’s a great addition to your wellness journey. It’s a timely reminder that the key to mental wellness might just lie within our own neurochemistry. Small, consistent habits can lead to profound transformation but seeking care to boost your ability to achieve these changes is available close to home. Whether you’re battling burnout, brain fog, OCD, addiction, insomnia, feeling depressed or anxious or simply curious about how your brain works. We, at Cromwell Medical Clinic, have the knowledge and treatment options to stimulate your own body to rebalance neurologically active chemicals.